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Hindi Case Report, J Sleep Disor Treat Care Vol: 4 Issue: 1
Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade
| Daniel A Barone1*, Christina M DINapoli1, Anne Maitland2 and Ana C Krieger1 |
| 1Weill Cornell Medical College Center for Sleep Medicine, New York, NY, USA |
| 2Comprehensive Allergy and Asthma Care, Allergy & Asthma Center in Tarrytown, NY, USA |
| Corresponding author : Daniel A. Barone, MD Assistant Professor of Neurology, Weill Cornell Medical College, Center for Sleep Medicine, 425 East 61st 5th Floor, New York, NY, 10065, USA Tel: 646-962-7378; Fax: 646-962-0455 E-mail: dab9192@med.cornell.edu |
| Received: July 18, 2014 Accepted: December 17, 2014 Published: December 19, 2014 |
| Citation: Barone DA, DINapoli CM, Maitland A, Krieger AC (2015) Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade. J Sleep Disor: Treat Care 4:1. doi:10.4172/2325-9639.1000102 |
Abstract
Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade
This report describes two patients with connective tissue disorders, Ehlers-Danlos syndrome and systemic lupus erythematosus (SLE), presenting with excessive daytime sleepiness. It has been suggested that these conditions involve activation of mast cells, which in turn is at least partially responsible for the symptoms of sleepiness. The two patients described were treated with H1 and H2 histamine blockers, and had experienced profound improvement in their subjective symptoms. These cases will hopefully inspire further research and discussion in this area.
