"The immune system is a system of biological structures and processes within an organism that protects against foreign invaders called antigens. To function properly, an immune system must detect a wide variety of foreign agents like pathogenic bacteria and viruses and distinguish them from the organism's own healthy tissue. The immune system protects the body against diseases. Basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants include phagocytosis, defensins, and the complement system. Humans have a more sophisticated defense mechanisms that includes the ability to adapt over time to recognize specific pathogens more efficiently. Journal of Primary & Acquired Immunodeficiency Research is a peer-reviewed scholarly journal that aims to publish the most complete and reliable source of information on the discoveries and current developments in all areas pertaining to Immunodeficiency. Journal of Primary & Acquired Immunodeficiency Research publishes results of research on Primary Immunodeficiency, Acquired Immunodeficiency, Diseases/Infections/Disorders associated with Immunodeficiency, and their Treatments. The Journal uses Editorial Manager System to maintain quality review process. Editorial Manager is an online manuscript submission, review and tracking system. Review process is performed by the editorial board members of Journal of Primary & Acquired Immunodeficiency Research; the validation by at least two independent reviewers followed by the editor’s approval is required for the acceptance of any citable manuscript for publication in the Journal. "