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Hindi Research Article, J Liver Dis Transplant Vol: 1 Issue: 1
Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy
| Moses M. Darpolor1*, David E. Kaplan2, Peter L. Pedersen3 and Jerry D. Glickson1 | |
| 1Departments of Radiology, University of Pennsylvania, Philadelphia, PA, USA | |
| 2Departments of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA | |
| 3Departments of Biological Chemistry and Oncology, Sidney Kimmel Cancer Research Center, and Center for Obesity Research & Metabolism, John Hopkins University, School of Medicine, Baltimore, MD, USA | |
| Corresponding author : Moses M. Darpolor, PhD University of Pennsylvania, Department of Radiology, B-6 Blockley Hall - 6021, 423 Guardian Drive, Philadelphia, PA 19104-6100, USA E-mail: mdarpolor@gmail.com |
|
| Received: July 13, 2012 Accepted: August 28, 2012 Published: August 31, 2012 | |
| Citation: Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD (2012) Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy. J Liver: Dis Transplant 1:1. doi:10.4172/2325-9612.1000101 |
Abstract
Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance
Spectroscopy
A characteristic feature of cancer cells is the alteration of their central carbon metabolism. It is generally acknowledged that for energy production cancer cells enhance their utilization of glycolysis and diminish that of oxidative phosphorylation irrespective of oxygen supply [1]. However, although mechanistic explanations for this enhanced glycolytic phenotype are controversial, it is likely due to the need for a versatile method for ATP production to serve as a direct form of energy, or as energy to drive both biosynthesis of vital intermediates for cell growth and provide anaplerotic flux for the tricarboxylic acid (TCA) cycle.
