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Hindi Review Article, J Immunodefic Disor Vol: 2 Issue: 1
Gene Therapy in Primary Immunodeficiencies
| Inês Rosinha, Laura Costa*, Mara Pinto, Natália Barbosa and Patrícia Rosinha | |
| Faculty of Medicine, University of Porto, Portugal | |
| Corresponding author : Laura Costa Faculty of Medicine, University of Porto, Portugal E-mail: laura.a.costa@hotmail.com |
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| Received: February 28, 2013 Accepted: May 30, 2013 Published: June 07, 2013 | |
| Citation: Rosinha I, Costa L, Pinto M, Barbosa N, Rosinha P (2012) Gene Therapy in Primary Immunodeficiencies. J Immunodefic Disor 2:1. doi:10.4172/2324-853X.1000103 |
Abstract
Gene Therapy in Primary Immunodeficiencies
Primary immunodeficiencies (PIDs) result from inherited mutations in genes involved in the production, function or survival of specific elements of the immune system (T, B, NK lymphocytes, neutrophils, antigen-presenting cells). Knowing that these elements derive from pluripotent hematopoietic stem cells, it has been tried to use allogeneic hematopoietic stem cell transplantation (HSCT) as an alternative for patients with a PID, which has proven to be an effective therapeutic approach leading to immune restoration.