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Hindi Research Article, J Genet Disor Genet Rep Vol: 2 Issue: 1
Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy
| Eric P Cohen1*, Marek Lenarczyk3, Brian L Fish3, Shuang Jia2, Martin J Hessner2 and John E Moulder3 | |
| 1Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA | |
| 2Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA | |
| 3Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA | |
| Corresponding author : Eric P Cohen Department of Medicine, Zablocki VAMC, 5000 W National Ave, Milwaukee, WI 53295, USA Tel: 1-414-384-2000; Fax: 1-414-383-9333 E-mail: eric.cohen@va.gov |
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| Received: October 07, 2012 Accepted: December 05, 2012 Published: December 10, 2012 | |
| Citation: Cohen EP, Lenarczyk M, Fish BL, Jia S, Hessner MJ, et al. (2013) Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy. J Genet Disor Genet Rep 2:1. doi:10.4172/2327-5790.1000101 |
Abstract
Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy
Chronic persistent oxidative stress has been proposed as a mechanism for late radiation injury to normal,tissue. Using biochemical, histological, and pharmacological techniques, we have not been able to confirm this hypothesis for late renal radiation injury. Gene expression may be more revealing,especially since the initial effects of radiation are to damage DNA.
