Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Editorial, J Liver Dis Transplant Vol: 4 Issue: 2
Endoplasmic Reticulum Stress in Drug-Induced Liver Injury and Liver Diseases: An Unlighted Novel Mechanism
| Erkekoglu P*, Koçer-GümüÃ?Â?el B, Elnour A and Bhagavathula AS | |
| Department of Toxicology, Hacettepe University, 06100, Ankara, Turkey | |
| Corresponding author : Pinar Erkekoglu Faculty of Pharmacy, Department of Toxicology, Hacettepe University, 06100, Ankara, Turkey Tel: +90 312 305 21 78; Fax: +90 312 311 47 77 E-mail: erkekp@yahoo.com |
|
| Received: October 06, 2015 Accepted: October 08, 2015 Published: October 12, 2015 | |
| Citation: Erkekoglu P, Koçer-Gümüsel B, Elnour A, Bhagavathula AS (2015) Endoplasmic Reticulum Stress in Drug-Induced Liver Injury and Liver Diseases: An Unlighted Novel Mechanism. J Liver: Dis Transplant 4:2. doi:10.4172/2325-9612.1000e109 |
Abstract
The endoplasmic reticulum (ER) is a very important organelle in the eukaryotic cells. It has two types: rough endoplasmic reticulum (rough ER, RER) and smooth endoplasmic reticulum (smooth ER, SER). ER plays a vital role in many cellular processes such as secretory and membrane protein synthesis, folding, assembly, trafficking and post-modulation. The lumen of the ER contains the highest concentration of Ca2+ within the cell because of active transport of calcium ions by Ca2+ ATPases and it is a unique environment in which an incredible process of protein quality control checking is performed.
