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Hindi Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 7
Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles- Modified Electrode
| H Heli1,2,3* |
| 1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
| 2Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran |
| 3Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran |
| Corresponding author : Dr. Heli H Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran Tel/Fax: +98 711 234 93 32 E-mail: hheli7@yahoo.com or heli@sums.ac.ir |
| Received: September 18, 2013 Accepted: November 14, 2013 Published: November 18, 2013 |
| Citation: Heli H (2013) Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles-Modified Electrode. J Nanomater Mol Nanotechnol 2:7. doi:10.4172/2324-8777.1000130 |
Abstract
Electrochemical Studies of Vitamin K3 and Its Interaction with Human Serum Albumin Using a Carbon Nanoparticles- Modified Electrode
The electrochemical behavior of vitamin K3 on a carbon nanoparticles-modified glassy carbon electrode surface and its interaction with human serum albumin were investigated. The results showed that vitamin K3 is reduced in a two-electron step. The diffusion coefficients of vitamin K3 was determined. Also, the heterogeneous electron transfer rate constant and charge transfer coefficient were evaluated using cyclic voltammetry, impedance spectroscopy and steady-state polarization measurements. Upon addition of human serum albumin to the vitamin K3 solution, both the cathodic and anodic peak currents were decreased; however, binding vitamin K3 to human serum albumin formed an electroreactive species. The percentage of interaction of vitamin K3 with protein was addressed.
