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Hindi Research Article, J Otol Rhinol Vol: 2 Issue: 3
Effect of Severity of Laryngopharyngeal Reflux Measured by Clinical Parameters on Laryngeal Mucin Gene Expression
| Mahmoud S Ali1,2*, David M Bulmer2, Peter Dettmar3 and Jeffrey P Pearson2 | |
| 1Department of Otolaryngology, Mansoura University Hospital, Mansoura University, Egypt | |
| 2Institute for Cell and Molecular Biosciences, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne, UK | |
| 3Castle Hill hospital, Castle Road, Cottingham, East Yorkshire, UK | |
| Corresponding author : Mahmoud S Ali Department of Otolaryngology, Mansoura University Hospital, Mansoura University, Egypt Tel: 07868710121 E-mail: msamomar@yahoo.co.uk |
|
| Received: March 27, 2013 Accepted: June 10, 2013 Published: June 18, 2013 | |
| Citation: Ali MS, Bulmer DM, Dettmar P, Pearson JP (2013) Effect of Severity of Laryngopharyngeal Reflux Measured by Clinical Parameters on Laryngeal Mucin Gene Expression. J Otol Rhinol 2:3. doi:10.4172/2324-8785.1000125 |
Abstract
Effect of Severity of Laryngopharyngeal Reflux Measured by Clinical Parameters on Laryngeal Mucin Gene Expression
Background: Cerebrospinal fluid (CSF) fistulae that present as intermittent rhinorrhea can be a diagnostic challenge. Many imaging modalities are currently used for detection of a CSF fistula, including invasive techniques such as CT Cisternography and Radionuclide Cisternography. The purpose of this study is to present our experience with non-invasive imaging of intermittent CSF rhinorrhea.
Methods: Retrospective chart review of New York University Medical Center patient database with suspected intermittent CSF rhinorrhea.
Results: Nine patients were included in this study; a β2-transferrin assay was performed when possible. All patients had imaging that included High-Resolution CT (HRCT), MR Cisternography (MRC), or a combination of the two. When HRCT was combined with MRC the sensitivity and accuracy of detecting and localizing a CSF fistula were both 100%.
Conclusion: Intermittent CSF rhinorrhea may be evaluated with HRCT and MR Cisternography, as these two modalities have good reliability and are non-invasive techniques.
