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Hindi Research Article, J Liver Dis Transplant Vol: 2 Issue: 1
The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients
| Zuhal Mert Altintas1*, Engin Altintas2, Orhan Sezgin2, Tuba Gokdogan Edgunlu1, Enver Ucbilek2, Erdinc Nayir3, Ibrahim Omer Barlas1 and Mehmet Emin Erdal1 | |
| 1Department of Medical Biology and Genetics, Mersin University School of Medicine, Mersin, Turkey | |
| 2Department of Gastroenterology, Mersin University School of Medicine, Mersin, Turkey | |
| 3Department of Internal Medicine, Mersin University School of Medicine, Mersin, Turkey | |
| Corresponding author : Zuhal Mert Altintas Department of Medical Biology and Genetics, Mersin University School of Medicine, Mersin, Turkey Tel: +90-324-361-00-01/1136; Fax: +90-324-361-00-00 E-mail: altintaszmert@gmail.com |
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| Received: December 14, 2012 Accepted: March 21, 2013 Published: March 25, 2013 | |
| Citation: Altintas ZM, Altintas E, Sezgin O, Edgunlu TG, Ucbilek E, et al. (2013) The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients. J Liver: Dis Transplant 2:1. doi:10.4172/2325-9612.1000108 |
Abstract
The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients
Ribavirin is a purine nucleoside analogue. Even though its mechanism of action is still controversial, it widely prevents the replication of DNA and RNA viruses through the inhibition of inosine monophosphate dehydrogenase, an essential enzyme in the synthesis of guanosine triphosphate. Currently, the treatment of patents with hepatitis C consists of interferon-α and ribavirin combination therapy.
