Biography
Dr. Paul Higgins is an honorable Editor-in-chief of the journal, Cell Biology: Research & Therapy. He is the professor and Director at Center for Cell Biology & Cancer Research, Albany Medical College, USA. Dr. Higgins did his PhD from New York University and Post Doctorate from Memorial Sloan-Kettering Cancer Center, New York, USA.
Research Interest
Dr. Higgins research focus on the molecular mechanisms underlying transcriptional regulation of the critical inflammation and fibrosis-promoting factor PAI-1 (plasminogen activator inhibitor-1; SERPINE1). PAI-1 is a major effector of human fibrotic disease where it promotes the development of, and maintains, the inflammatory and angiogenic responses. His current efforts focus on creation of molecular genetics "reagents", including PAI-1 oligonucleotide decoys, antisense constructs, silencing RNAs and micro-RNAs that target PAI-1 gene expression in the fibrotic stroma as well as in angiogenic endothelial cells.
Related Publications
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Human Fungal Infections: Need to Improve Diagnosis with New Biomarkers Developed by Translational Research
Editorial: Mol Med Ther 2012, 1:1
DOI: 10.4172/2324-8769.1000e101
Aamir Shahzad, Randall J Cohrs, Adong Shen and Cornelia Lass-Flörl
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Performance of Commercial Interferon-γ Release Assays for Screening Latent Tuberculosis Infection: A Meta-Analysis
Research Article: Mol Med Ther 2012, 1:2
DOI: 10.4172/2324-8769.1000103
Lin Sun, Qingqin Yin, Jianling Tian, Qing Miao, Fang Xu, Jing Xiao, Chen Shen, Weiwei Jiao, Cornelia Lass-Flörl, Aamir Shahzad and Adong Shen
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Prolyl Hydroxylases in fight or flight
Editorial: Mol Med Ther 2012, 1:1
DOI: 10.4172/2324-8769.1000e102
Anne-Theres Henze, Rodrigo Leite de Oliveira and Massimiliano Mazzone
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Parkinsonâs Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective
Review Article: Mol Med Ther 2012, 1:2
DOI: 10.4172/2324-8769.1000104
Alan R. Hipkiss
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Regulation of Coronary Vasomotor Function by Reactive Oxygen Species
Review Article: Mol Med Ther 2012, 1:1
DOI: 10.4172/2324-8769.1000101
Lih Kuo, Naris Thengchaisri and Travis W. Hein
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Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis
Research Article: Mol Med Ther 2012, 1:2
DOI: 10.4172/2324-8769.1000105
Xuejun H. Parsons, James F. Parsons and Dennis A. Moore
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Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease
Short Communication: Mol Med Ther 2012, 1:1
DOI: 10.4172/2324-8769.1000102
Tessa M. Simone and Paul J. Higgins
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Novel Combinatorial Therapeutic Targeting of PAI-1(SERPINE1) Gene Expression in Alzheimerâs Disease
Short Communication: Mol Med Ther 2012, 1:2
DOI: 10.4172/2324-8769.1000106
Stacie M. Kutz, Craig E. Higgins and Paul J. Higgins