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Hindi Research Article, J Otol Rhinol Vol: 4 Issue: 2
Does Helicobacter Pylori have a role in Cholesteatoma?
| Collin Sutton1, Adam Fonseca2, Anne Kane2, Tyler DeBlieux2, Randall Craver3, Rodolfo E Bégué4 and Anita Jeyakumar1* | |
| 1Department of Otorhinolaryngology, Louisiana State University-Health Science Center, New Orleans, LA, USA | |
| 2Louisiana State University-Health Science Center, New Orleans, LA, USA | |
| 3Department of Pathology, Louisiana State University-Health Science Center, New Orleans, LA, USA | |
| 4Department of Pediatrics, Louisiana State University-Health Science Center, New Orleans, LA, USA | |
| Corresponding author : Anita Jeyakumar, MD, MS FACS, Department of Otorhinolaryngology, Louisiana State University-Health Science Center, 200 Henry Clay ave, Ste 4119, New Orleans, LA 70118, USA Tel: 504-896-9832; Fax: 504-896-9296 E-mail: ajeyak@lsuhsc.edu |
|
| Received: July 11, 2014 Accepted: December 12, 2014 Published: April 03, 2015 | |
| Citation: Sutton C, Fonseca A, Kane A, DeBlieux T, Craver R, et al. (2015) Does Helicobacter Pylori have a role in Cholesteatoma?. J Otol Rhinol 4:2. doi:10.4172/2324-8785.1000220 |
Abstract
Does Helicobacter Pylori have a role in Cholesteatoma?
Background: The pathophysiology of cholesteatoma is unclear but chronic inflammation seems a common factor. Helicobacter pylori can colonize nasopharynx and middle ear.
Objective: To investigate whether H. pylori may have a role in cholesteatoma.
Study Design: Age-stratified, cholesteatoma evaluation for the presence of H. pylori.
Method: 30 cholesteatoma biopsies were selected for review: 11 were age 8 months – 5 years, 11 were age 6-10 years, and 8 were 11-15 years. All samples had to have cholesteatoma matrix, capsule and surrounding connective tissue. The slides were prepared using hematoxylin and eosin (H & E) stains and immunohistochemistry (IHC) stains for H. pylori using Anti- Helicobacter pylori clone (SP48). All the slides were evaluated for H. pylori by an experienced pathologist. All cholesteatoma specimen did not have H. pylori (0% incidence of H. pylori).
Results: H. pylori organisms were not seen on any of the specimens.
Conclusions: Our preliminary data does not suggest a role of H. pylori in the etiology of cholesteatoma.
