PO2 at seal level is available in the atmosphere and the oxygen demands of mitochondria are large. PO2 decreases in every stage of oxygen transport system,; this disease is figuratively called the oxygen cascade. At high altitudes, the decrease in barometric pressure reduces the amount of oxygen available in environment, Mechanisms that compensate for the decreased availability of oxygen in the environment include changes in the intracellular enzyme systems to allow them to function at low levels of oxygen and changes in the oxygen transport system to increase the amount of oxygen delivered. The latter is the primary compensatory mechanism. Changes occur at all levels of the oxygen transport system, namely, ventilation, pulmonary diffusion, circulation, and tissue diffusion. Impact Factor is a measure of the frequency with which the ""average article"" in a journal has been cited in a given period of time. The impact factor is used as standard dimension and the relative importance of a scientific journal within its field. The Impact Factor is calculated by several scientific methods including citation analysis. International Journal of Cardiovascular Research emerges as a best indexed journal with impact factor compared to other competitive journals focuses on hypertension along with some minor classifications like high altitude pulmonary hypertension and other cardiology studies by bringing up the recent research to global scientific community through its publications. The papers submitted are undergone through perfect plagiarism checks, later peer reviewed by the expert group and published after through revisions"