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Hindi Research Article, J Clin Exp Oncol S Vol: 0 Issue: 0
Biophysical Pathology in Cancer Transformation
| JiÃ?Â?í Pokorný1* and Jan Pokorný2,3 | |
| 1Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, 182 51 Prague 8, Czech Republic | |
| 2Institute of Physics, Academy of Sciences of the Czech Republic, Na Slovance 2, 182 21 Prague 8, Czech Republic | |
| 3Dept. of Materials Science and Engineering, The University of Sheffield, Mappin Street, S1 3JD Sheffield, UK | |
| Corresponding author :JiÃ?Â?í Pokorný Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, 182 51 Prague 8, Czech Republic Tel: +(420) 266773432; Fax: 284680222 E-mail: pokorny@ufe.cz |
|
| Received: August 05, 2013 Accepted: October 24, 2013 Published: November 12, 2013 | |
| Citation: Pokorný J, Pokorný J (2013) Biophysical Pathology in Cancer Transformation. J Clin Exp Oncol S1:003 doi:10.4172/2324-9110.S1-003 |
Abstract
Biophysical Pathology in Cancer Transformation
Energy supply to biological systems excites and sustains the state far from thermodynamic equilibrium which is a necessary condition for life. Energy processing by mitochondria forms a strong static electric field which causes ordering of water. These physical states establish conditions for generation of the electromagnetic field by microtubules (microtubule generation is postulated). Disturbances of the energy supply system result in pathological states. In cancers the physical pathological state is caused by disturbances of oxidative metabolism. Mitochondrial dysfunction is formed either in cancer cells (the normal Warburg effect) or in fibroblasts associated with cancer cells (the reverse Warburg effect). Dysfunctional mitochondria display inhibited pyruvate transfer into matrix space, decreased oxidative energy metabolism, low static electric field, and low level of water ordering around them
