To understand complex biological systems requires the integration of experimental and computational research which in other words can be called as a systems biology approach. Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The objective of systems biology can be defined as the understanding of network behavior, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. By discovering how function arises in dynamic interactions, systems biology addresses the missing links between molecules and physiology. Top-down systems biology identifies molecular interaction networks on the basis of correlated molecular behavior observed in genome-wide studies. Bottom-up systems biology examines the mechanisms through which functional properties arise in the interactions of known components A hybrid journal offers authors the choice of publishing via the ‘traditional’ method of access to articles via a subscription OR making individual articles freely available online (often termed open access). Hybrid journals usually charge authors, their institutions or funders an additional fee for making an article open access. The open access article will appear in the subscription-based print and electronic versions as normal. Open access articles in hybrid journals should be marked as ‘open access’ or have a symbol that signifies they are open access. Journal of Biocatalysis & Biotransformation emerges as a best indexed, hybrid journal with impact factor compared to other competitive journals focusing on Biochemistry, its classifications like biological systems by bringing up the recent research to global scientific community through its publications. The papers submitted are undergone through perfect plagiarism checks, later peer reviewed by the expert group and published after through revisions.