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Hindi Research Article, J Virol Antivir Res Vol: 3 Issue: 4
Basant, a Polyherbal Topical Microbicide Candidate Inhibits different Clades of Both CCR5 and CXCR4 Tropic, Lab-Adapted and Primary Isolates of Human Immunodeficiency Virus-1 in Vitro Infection
| Maciej B Maselko1,2†, Rupali S Joshi3†, Meagan Prescott1, GP Talwar4, Smita Kulkarni3, Manoj K.Pastey1* | |
| 1Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA | |
| 2Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA | |
| 3National AIDS Research Institute, Pune. 73, G Block, MIDC, Bhosari, Pune – 411 026, India | |
| 4Talwar Research Foundation, E-8, Neb Valley, Neb Sarai, New Delhi 110068, India | |
| † Equal Contribution. | |
| Corresponding author : Manoj K. Pastey 210 Dryden Hall, Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA Tel: (541)737-3940; Fax: (541)737-2730 E-mail: Manoj.Pastey@oregonstate.edu |
|
| Received: March 21, 2014 Accepted: November 07, 2014 Published: November 12, 2014 | |
| Citation: Maselko MB, Joshi RS, Prescott M, Talwar GP, Kulkarni S, et al.(2014) Basant, a Polyherbal Topical Microbicide Candidate Inhibits different Clades of Both CCR5 and CXCR4 Tropic, Lab-Adapted and Primary Isolates of Human Immunodeficiency Virus-1 in Vitro Infection. J Virol Antivir Res 3:4. doi:10.4172/2324-8955.1000131 |
Abstract
Topical microbicides applied to the vaginal mucosa as pre-exposure prophylactic measures for controlling sexually transmitted diseases have great potential to combat theHIV-1 pandemic in the developing world. Basant is a polyherbal topical microbicide candidate with demonstrated activity against CXCR4 co-receptor tropic HIV-1 as well as fungal and bacterial sexually transmitted infections. The current study demonstrates that Basant is effective against both CCR5 and CXCR4 tropic HIV-1 lab-adapted strains and primary isolates from different clades. We also investigate the kinetics of Basant inhibition as compared to the fusion inhibitor Enfuvirtide and report that Basant inhibits HIV-1 at an early stage of infection. We conclude that Basant may be considered as a potential candidate for use as an effective vaginal microbicide in preventing HIV-1 transmission
