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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Shivangi Author
Subjects of specialization
Affiliation
PCR, Gel Electrophoresis, Cell Culture, DNA, Cloning
CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India
Biography
Shivangi Mathuria currently works at the Respiratory Disease Biology Research Area (IGIB), Institute of Genomics and Integrative Biology. Shivangi does research in Molecular Biology. Essential biochemical, biophysical and computational inputs on efficient functioning of Mycobacterium tuberculosis H37Rv FtsY is one of the research works of Shivangi Mathuria.
Publications
Review Article Open Access
Cholesterol Metabolism: As a Promising Target Candidate for Tuberculosis Treatment by Nanomedicine
Author(s): Parv Tanwar, Shivangi and Laxman S Meena*
We are facing a tremendous need to develop anti-tuberculosis (TB) drugs due to extreme rise in incidence and mortal cases of this disease. Mycobacterium tuberculosis (M. tuberculosis), the causative agent behind this malady have attained the drug-resistant characteristic by adding mutation at its genetic level and modifying their metabolic pathways. An important metabolic pathway employed in the bacterium is cholesterol metabolic pathway. Cholesterol is needed by the bacterium for attachment, entry, as a major nutrient source, persistence, and infection in the host. Manifold roles of cholesterol in M. tuberculosis making it an important mark to target the survival and virulence of the bacterium. Genetic regulation of cholesterol metabolism is a complex phenomenon. This review emphasizes... view more»
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