Parv Tanwar Author

Review Article Open Access

Cholesterol Metabolism: As a Promising Target Candidate for Tuberculosis Treatment by Nanomedicine

Author(s):

Parv Tanwar, Shivangi and Laxman S Meena* 

We are facing a tremendous need to develop anti-tuberculosis (TB) drugs due to extreme rise in incidence and mortal cases of this disease. Mycobacterium tuberculosis (M. tuberculosis), the causative agent behind this malady have attained the drug-resistant characteristic by adding mutation at its genetic level and modifying their metabolic pathways. An important metabolic pathway employed in the bacterium is cholesterol metabolic pathway. Cholesterol is needed by the bacterium for attachment, entry, as a major nutrient source, persistence, and infection in the host. Manifold roles of cholesterol in M. tuberculosis making it an important mark to target the survival and virulence of the bacterium. Genetic regulation of cholesterol metabolism is a complex phenomenon. This review emphasizes... view more»

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