HIV and AIDS Research Journal

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Nageen Hussain Author

Nageen1704@Hotmail.Com 00 92 3224736630

Subjects of specialization
HIV

Affiliation
Assistant Professor, MMG Department, University of the Punjab-Lahore, MMG Department, PU-LHR, Pakistan

Biography

 ASSISTANT PROFESSOR, UNIVERSITY OF THE PUNJAB: LAHORE, PUNJAB, PAKISTAN. HE HAS DONE  PHD  IN MICROBIOLOGY AND MOLECULAR GENETICS UNDER UNIVERSITY OF THE PUNJAB: LAHORE, PUNJAB, PAKISTAN. HIS RESEARCH INTERESTS INCLUDE HIV; AIDS; FOXP3; Tregs; CD4.
 

Publications

Review Article Open Access

FOXP3 Gene and T Regulatory Cells Behavior in AIDS Patients

Author(s):

Aqsa Javaid and Nageen Hussain

Regulatory T cells (CD4+CD25+) recruited by FOXP3 gene, are necessary for the initiation and conservation of self-tolerance and avoidance of autoimmunity by decreasing the auto reactive T cells. According to one research, it was being planned to examine the aspect of Tregs in immune system of HIV+ patients and noticed that number of Tregs are above the normal but function is extremely decreased with noticeable HIV-1 RNA in plasma in contrast to healthy control.. In agreement with other analysis, the effect of HIV infection on regulatory T cells (CD4+CD25high) was figured out via flow cytometry and FOXP3 quantitative reverse transcriptase PCR. FOXP3 mRNA was taken and calibrated in purified CD4+ lymphocytes or peripheral blood mononuclear cells from HIV+ lymp... view more»

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