Journal of Genetic Disorders & Genetic ReportsISSN: 2327-5790

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Mani A Author

Man@gmail.com

Subjects of specialization
Oral sub mucous fibrosis

Affiliation
Department of Public Health Dentistry, People

Biography

Mr. Mani A, belongs to the department of Public Health Dentistry, interest in the field of  Human leukocyte antigens; Oral sub mucous fibrosis; Smoking; Tobacco, from People’s College of Dental Sciences, Peoples University, Bhopal, India

Publications

Research Article Subscription

Association of HLA Typing with Nicotine Dependence by Extraction of Salivary DNA among Indian Population

Author(s):

Purohit A, Purohit BM, Mani A and Bhambal A

Objectives

Tobacco smoking is one of the major public health problems the world facing today. With more and more diseases being associated with alleles of the human leukocyte antigens (HLA) region than any other genetic region, objective of the study was to explore genetic association of smoking behavior with specific HLA Class II DQB1*0503 and HLA DRB1*0301 alleles.

Methods Genomic DNA was extracted from saliva of 39 patients divided among tobacco smokers and controls. This was followed by PCR with sequence specific primer of HLA-DQB1*0503 and HLA DRB1*0301 allele, visualized under 2% agarose gel.

Results

Significant difference was observed between tobacco smo... view more»

DOI: 10.4172/2327-5790.1000170

Abstract HTML PDF

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