Aksu M Author

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The Impact of Sleep Deprivation on Plasma Leptin and Ghrelin Levels in Narcoleptic Patients

Author(s):

Korkmaz S, Aksu M, Tuna M, Baskol G, Bayram F and Hallett M

Background: Narcoleptic patients have an increased rate of comorbid conditions such as obesity, type 2-diabetes. Those conditions have been thought to be associated with altered feeding regulating hormones including leptin, ghrelin and impaired glucose tolerance in narcoleptic patients. Therefore, the current study aimed to characterize basal plasma leptin and ghrelin levels and to assess glucose metabolism in narcoleptic patients and to determine whether the biologic effects of sleep deprivation seen in healthy population would be the same as those in narcoleptic patients.

Method: Following usual night's sleep, 24 hours sleep deprivation was performed on ten narcolepsy patients (five men, five women) and age, sex and body mass index (BMI) match... view more»

DOI: 10.4172/2325-9639.1000188

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