Update systematic review of skin substitutes versus standard of care on diabetic foot ulcer healing

Diabetic patients are at an increased risk of developing chronic adverse events due to diabetes associated complications. Diabetic foot ulcers occur in about 15% of all diabetic patients and if improperly managed and poorly healed, can lead to atraumatic amputation of the foot. Although the current standard of care (SOC) protocol has helped the healing process of DFUs, there is still a need for clarification of product use. This review seeks to look at biologic agents and their practicality in implementation as an adjuvant therapy by comparing healing rates in patients treated with SOC and biologic agents as compared to patients who were only treated with SOC.