Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review

Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review

Abstract

Transdermal iontophoresis is one of the most studied active technique involves passage of small electrical current to drive the charged drug molecules through the skin. However, iontophoresis is not suitable for nonpolar drugs as they lack any charge and possess poor water solubility. Therefore, the main objective of this review was to discuss the potential approaches to render the lipophilic drugs amenable to iontophoretic delivery across the skin.