Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research

Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research

The Thioredoxin (Trx) system, ubiquitous from Archaea to man, participates in several metabolic processes, e.g. intracellular signaling of reactive oxygen species (ROS), transcription, DNA synthesis. Alterations in this system have been shown to induce ROS-related cardiovascular disorders, myocarditis and ischemia. Recent findings indicate that the Trx system mediates redoxinduced cell death, in response to anticancer agents to a large extent. Thioredoxin is a member of the Trx system, that also includes Trx reductase (TrxR) and NADPH.