Therapeutic Effects of Sinomenine Microemulsion- Based Hydrogel on Adjuvant- Induced Arthritis in Rats

Therapeutic Effects of Sinomenine Microemulsion- Based Hydrogel on Adjuvant-Induced Arthritis in Rats

Sinomenine is an alkaloid isolated from the traditional Chinese medicinal herb Sinomenium acutum, which has been used for the treatment of rheumatoid arthritis in China. The objective of this work was to investigate the effect of sinomenine microemulsion-based hydrogel (SMBH) on Freund’s complete adjuvant-induced arthritis(AA) in Wistar rats. The SMBH was formulated as follows: 4%sinomenine, 2% oleic acid, 16.7% Tween-20, 41% distilled water,33.3% absolute alcohol, 3% menthol, and 2% carbomer (w/w).Treatment was started on the seventh day after AA was induced. All groups were daily applied to the hind feet skin with SMBH or sinomenine gel (SG) for 14 days.