The utilization of laser-induced nucleic acid amplification reaction on the surface of composite magnetic nanoparticles for rapid and semi-quantitative genes detection

Nucleic acid testing (NAT) is regarded as a highly sensitive and specific method for infectious disease screening. Among NAT technologies, polymerase chain reaction (PCR) and loopmediated isothermal amplification (LAMP) are two common technologies in fundamental research and clinical applications for nuclei acid amplification, which the targeted genes at accurate thermal-control conditions. However, while implementing these two technologies in the external heater (e.g., PCR machine), indirect heat transfer not only leads to massive amounts of energy consumption but increases the cost of assembling a complicated and huge-volume thermal-control system.