The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

Ribavirin is a purine nucleoside analogue. Even though its mechanism of action is still controversial, it widely prevents the replication of DNA and RNA viruses through the inhibition of inosine monophosphate dehydrogenase, an essential enzyme in the synthesis of guanosine triphosphate. Currently, the treatment of patents with hepatitis C consists of interferon-α and ribavirin combination therapy.