Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine. It is the most abundant non-protein thiol in the cell, and is present at 5-10 mM in hepatocytes. GSH scavenges reactive oxygen species (ROS) and acts as a cofactor in the metabolism of xenobiotics through reduction and conjugation reactions. Several methods have been used in vivo and in vitro to study the effects of short-term GSH depletion on the hepatocyte cell cycle.