Survey of ethanomedicinal plants from Eastern Ghats, Tamil Nadu, India with special reference to neurodisorder using in silico and in vitro approaches

The most second common neurodegenerative disorder is Parkinson disease, which completely affects standard of life, causes dependency and premature mortality of the diseased person. The present study aims to document the data about the traditional uses of plants in health care trainers among local peoples of areas which may lead to natural drug invention development. The collected specimens were statistically analyzed. Effective phytocompounds and their mode of interaction were analyzed by various bioinformatics tools. Further, cell line activity also analyzed. During this investigation, totally 235 field trips and 194 days spent for gathering knowledge from137 informants. All the documented plants were statistically analyzed by FC, RFC, UV, RI, CI, FI and Pearson correlation coefficient. Homology modelling, binding site validation, molecular docking and MD simulations were studied. Free radical scavenging and antioxidant activity was analyzed against PC12 cell line. Totally, 85 medicinal plant species belonging to 73 families were documented for the treatment of 17 different ailments. Among them, 20 plants were used for neuro disorder and their phytocompounds were docked with Parkinson disease causing receptor (DJ1). Punigluconin (Phyllanthus emblica) is potential docking score and it was proved good binding affinities. P. emblica fruit extract has excellent antioxidant and radical scavenging activity. This is the first time the neuroprotective effects of P. emblica have been reported in human neural cell line. Finally, conclusion of this study Punigluconin is most suitable drug candidate for Parkinson disorder.