Stem Cell Therapy for Amyotrophic Lateral Sclerosis:Yesterday, Today and Tomorrow

Stem Cell Therapy for Amyotrophic Lateral Sclerosis:Yesterday, Today and Tomorrow

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, which have no any effective treatment method. There are various pathophysiological processes underlying the disease such as oxidative stress, glutamate toxicity, inflammation and loss of the glial neurotrophic support. There is no cure yet for ALS but there are many clinical trials that focused different therapeutic targets. One of the most popular treatment methods is cell transplantation. The cellbased therapies are promising for ALS patients with many evidences including beneficial effects in protection neurons and replacement of degenerated neurons.