Squamous Cell Carcinoma with Verrucous Features of the Tongue: A Case Report

Squamous cell carcinomas with verrucous features of the tongue are rare and distinct tumors that arise from the mucosa of the tongue. They are often associated with smoking and alcohol use, but can also occur in patients with no history of tobacco or alcohol consumption. This type of cancer is considered a subtype of squamous cell carcinoma, but has distinct characteristics that differentiate it from other forms of squamous cell carcinomas. Several treatment options are available, but there is no consensus on the best approach. We report a case of squamous cell carcinoma with verrucous features of the tongue in a 68-year-old patient and study the peculiarities of managing this type of lesion. Our patient underwent an MRI and biopsy confirming the histological type of the lesion. Surgical intervention was not feasible due to the size of the tumor, so we opted for a systemic neoadjuvant treatment with methotrexate followed by radiotherapy.