Spinal Cord Injury-Induced Discharges Modify the Function of Glutamatergic System and Improve Ground and Skilled Locomotor Control

Spinal Cord Injury-Induced Discharges Modify the Function of Glutamatergic System and Improve Ground and Skilled Locomotor Control

The injury of the spinal cord evokes intense neuronal activity of the spinal neurons. It has been always assumed that this excessive activity, correlated with a massive release of excitatory neurotransmitter, glutamate would impair functional recovery. This assumption constituted a base for developing many pharmacological treatments for acute spinal cord injury (SCI) aimed at reduction of this hyperactivity.