Role of Bioelectricity in the Regeneration

behaviors, including development, wound healing, Cancer progression, and tissue regeneration. Specifically, during tissue regeneration, two events during which stem cells actively proliferate and differentiate, endogenous electrical signals (like membrane potential (Vmem)) plays an important role. Membrane potential (Vmem) refers to the voltage difference across a cell’s bilayer membrane that is established by the balance of intracellular and extracellular ionic concentrations. Although maintenance of ionic homeostasis is a critical feature of cell viability and metabolism, a clear relationship has been suggested between the Vmem levels and the cell functions like proliferation and differentiation.