Revisiting the Role of TLR/IRAK Signaling and its Therapeutic Potential in Cancer

Interleukin-1 receptor-associated kinase (IRAK) family consistsof four members: IRAK1, IRAK2, IRAK3/M and IRAK4. They are key downstream mediators of toll-like receptor (TLR) and interleukin-1 receptor (IL1R) pathways.In particular, TLR, a family of transmembrane pattern recognition receptor (PRR), play a crucial role in the induction of innate and adaptive immune responds against microbial infection, tissue injury and also cancer.