Phosphorylase Kinase Inhibition with Curcumin in Psoriasis

Psoriasis is an inflammatory disease with a genetic component. The disease activity is characterized by unique epidermal proliferative kinetics, with specific clinical, histological and immunohistochemical markers of psoriatic hyper proliferation, including the expression of proliferating cell nuclear antigen (PCNA) as shown by the Ki-67 immunohistochemical marker, Observations of depletion of glycogen granules in active psoriasis has led to the identification of elevated Phosphorylase kinase (PhK) activity in psoriasis, with elevated PhK levels correlating with the presence of specific markers of psoriatic hyper proliferation.