Non-alcoholic Fatty Liver Disease and Hepatic Lipotoxicity

Obesity has reached pandemic proportions around the world. Its secondary sequelae-nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders for people of all ages. There is evidence that up to one-third of the population developed NAFLD was due to obesity and its associated metabolic disorders [1]. On the other hand, approximately one-third of hepatocellular carcinoma (HCC) patients do not have a medical history with etiology of infection with hepatitis B or hepatitis C, thus frequently diagnosing the malady from idiopathic or NAFLD [2].