NLRC5/CITA: A Novel Regulator of Class I Major Histocompatibility Complex Genes

NLRC5/CITA: A Novel Regulator of Class I Major Histocompatibility Complex Genes

In 1936, Peter Gorer reported one of the most significant work in the history of immunology; the first identification of alloantigen using serum from immunized rabbits and his own blood. This led to the discovery of the Major Histocompatibility Complex (MHC) by his coworker, George Snell at the Jackson Laboratories. After three quarters of a century, this year, 5 laboratories independently reported that mice deficient for NLRC5 display impaired expression of MHC class I molecules, confirming that NLRC5 is a MHC class I transactivator. What does this mean to us?