New Insights into the Molecular Mechanisms of Phthalate-Caused Hepatotoxicity: Novel Epigenetic Alterations

Hepatocellular carcinoma (HCC) is one of the most frequent and life-threatening cancers and the most severe complication of chronic liver disease. It represents approximately 85% of liver cancers. Its incidence is not only increasing worldwide in the past decade, but is also a leading cause of cancer-related deaths worldwide.