Kidney Dis-function, As a Manifestation of Systemic Effects of Chronic Obstructive Lung Disease

At present, COPD is considered as a disease with a systemic manifestation [1,2]. One of the most important extrapulmonary effects of COPD is renal dysfunction [3], which exacerbates the general background of the course and prognosis of the disease. Purpose: To study risk factors, as well as the contribution of systemic effects of chronic obstructive pulmonary disease to the development of renal pathology. Materials and methods: We studied 121 patients with stage I – IV COPD among a man (n = 74) and a woman (n = 74), the average age was 58.5 years. All subjects were divided into 4 clinical and control groups. The concentration level of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF alpha) was determined. Statistically significant results were considered level p <0.05. Results. In patients with COPD, 3 or more risk factors for the development of CKD have been identified. It was found that as the level of forced expiratory volume per second (FEV1) decreases, the average values of mycroalbuminuria (MAU) and cystatin C increase (table 1). The total frequency of cases of chronic kidney disease CKD (S1) at all stages of COPD in determining GFR by creatinine was 41.6%, S2–57.2%, S3 - 0.41%. When determining GFR using cystatin C, the frequency of stage S1 of CKD was 17.7%, S2 - 43.7%, S3 - 36.4% and S4 - 1.04%.