Ischemia-Reperfusion in the Kidneys: A Comprehensive Exploration of Pathogenesis and Intervention

Renal Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological phenomenon that occurs when the blood supply to the kidneys is temporarily disrupted (ischemia) and subsequently restored (reperfusion). This process can lead to significant damage to renal tissues and is implicated in various clinical scenarios, including kidney transplantation, certain surgeries, and conditions like acute kidney injury (AKI).