Investigation of Serum oxLDL, anti-oxLDL Antibody, MMP-9 and hsCRP Levels in Patients with Angiographically Defined Ruptured of Coronary Plaques

Background

When the coronary atherosclerotic plaque becomes vulnerable, it easily ruptures with subsequent thrombus formation, leading to acute myocardial infarction. Prior studies indicate that oxLDL, antioxLDL antibody, MMP-9, hsCRP play a key role in pathogenesis of plaque rupture. To study the involvement of oxLDL, anti-oxLDL antibody, MMP-9 and hsCRP in the pathogenesis of unstable coronary plaque

Methods: The study enrolled 80 consecutive patients with coronary artery disease who underwent PCI. The case group (n=40) should have a unstable coronary plaque, confirmed by conventional

angiography, whereas control group (n=40) should have stable coronary atherosclerosis. Serum oxLDL, anti-oxLDL antibody, MMP-9 levels was determined by ELISA. The hsCRP detected method on the automated analyzer. Gensini and SYNTAX score were also utilized for assessing the severity of coronary artery disease.

Results: Serum oxLDL (p=0.01), anti-oxLDL antibody (p<0.001), MMP-9 (p<0.001), hsCRP (p=0.009) in the case group were more than in the control group. The binary logistic regression analysis shows that MMP-9 (β=0.985, p<0.001), anti-oxLDL antibody (β=0.892, p<0.001), hsCRP (β=0.041, p=0.005), oxLDL (β=0.011, p=0.016) may play a role in the unstable coronary plaque. ROC Curve analysis shows that MMP-9 (area=0.87, p<0.001) variance is more than anti-oxLDL antibody (area=0.78, p<0.001), hsCRP (area=0.73, p<0.001), oxLDL (area=0.63, p=0.038) making it a diagnostically beneficial for the vulnerable plaque. Gensini score correlated with anti-oxLDL antibody (r=0.25, p=0.026), MMP-9

(r=0.42, p<0.001). But SYNTAX score correlated with anti-oxLDL antibody (r=0.41, p<0.001), MMP-9 (r=0.20, p<0.001)

Conclusion: The serum oxLDL, anti-oxLDL antibody, MMP-9 and hsCRP are significantly involved in the unstable coronary plaque.