Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade

Improvement of Sleepiness in Connective Tissue Disorders Following H1/H2 Blockade

This report describes two patients with connective tissue disorders, Ehlers-Danlos syndrome and systemic lupus erythematosus (SLE), presenting with excessive daytime sleepiness. It has been suggested that these conditions involve activation of mast cells, which in turn is at least partially responsible for the symptoms of sleepiness. The two patients described were treated with H1 and H2 histamine blockers, and had experienced profound improvement in their subjective symptoms. These cases will hopefully inspire further research and discussion in this area.