Gonadotropin-Releasing Hormone Immunization to Treat Urethral Sphincter Mechanism Incompetence in a Bitch that Experienced an Adverse Reaction to Phenylpropanolamine

Gonadotropin-Releasing Hormone Immunization to Treat Urethral Sphincter Mechanism Incompetence in a Bitch that Experienced an Adverse Reaction to Phenylpropanolamine

A 12 year old spayed female Queensland heeler mix was presented for the evaluation of unconscious urine leakage that occurred when the dog was sleeping. Urinalysis revealed no abnormalities and the dog was diagnosed with urethral sphincter mechanism incompetence. Phenylpropanolamine was prescribed and resolved incontinence but resulted in lethargy, anxiety, and nasal and ocular discharge. Discontinuation of phenylpropanolamine resolved these symptoms, but incontinence recurred. The dog was then treated by immunizing against GnRH.