Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis

Genome-Scale Mapping of MicroRNA Signatures in Human Embryonic Stem Cell Neurogenesis

To date, lacking of a clinically-suitable source of engraftable human stem/progenitor cells with adequate neurogenic potential has been the major setback in developing effective cell-based therapies against a wide range of neurological disorders. Derivation of human embryonic stem cells (hESCs) provides a powerful tool to investigate the molecular controls in human embryonic neurogenesis as well as an unlimited source to generate the diversity of human neuronal cell types in the developing CNS for repair.