Formulation and Evaluation of Microemulgel Containing Tizanidine Hydrochloride

The transdermal applications of a drug to the oral mucosa offer the potential advantages of delivering the drug directly to the site of action and possibly delivering the drug for an extended period of time. Recently Microemulgel has emerged as one of the most interesting topical preparations pharmaceutics field. They are relatively free of serious side effects .The use of Microemulgel as a delivery system has several advantages such as thixotropic, easily spreadable, non-staining, emollient, bio-friendly, clear, transparent & elegant appearance, the objectives of this study was aimed to develop and formulate Tizanidine hydrochloride, as a skeletal muscle relaxant. Tizanidine hydrochloride is used for the treatment of painful muscle spasm, spinal cord injury and in the treatment of muscle spasticity in spinal cord disease.