Exploring the Impactful Role of Kidneys in Iron Metabolism

Iron is an essential element for various physiological processes in the human body, playing a crucial role in oxygen transport, energy production, and cellular function. While the liver is traditionally recognized as a central player in iron metabolism, the kidneys also play a significant and intricate role in maintaining iron homeostasis. Iron metabolism is a dynamic process involving the absorption, distribution, utilization, and recycling of iron within the body. Dietary iron is absorbed in the duodenum and upper jejunum, and once in circulation, it is bound to transferrin, a protein that transports iron throughout the body. Iron is utilized for the synthesis of hemoglobin and other essential proteins, and any excess iron is stored in the liver, primarily in the form of ferritin. The regulation of iron levels is tightly controlled to prevent deficiencies or excess accumulation, as both can lead to serious health issues.