Endometrium Cancer: Evidence of Cooperative Effect of P53 Codon 72 and ACP1 Genetic Polymorphisms on Cancer Grade

Objective: In the present paper we have searched for a possible cooperative effect of p53 codon 72 and ACP1 genetic polymorphisms on cancer grade. Methods: 69 women with endometrium cancer and 696 adults without cancer have been studied. P53 codon 72 and ACP1 genotypes were determined by DNA analysis. Results: The analysis has shown a cooperative interaction between ACP1 and p53 codon 72 concerning the effect on cancer grade: the proportion of the joint genotype *Arg/*Arg carrying the low activity *A/*A and *A/*B ACP1 genotypes is lower in high grade than in low grade. The proportion of gametic type *A/*Arg is significantly lower in high than in low grade cancer. Conclusion: The combination of the effect of low activity ACP1 that may favor cellular growth with the increase of apoptosis due to *Arg allele could act against the progression towards forms with immature and undifferentiated cells protecting from severe manifestation of cancer.