Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial

Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial

Objective: The aim of this randomized, double-blinded, placebocontrolled trial was to assess the efficacy of adaptogens on the physical and emotional stress-induced loss of concentration, coordination, fatigue and hormonal changes in 215 elite athletes. This study explores two formulations, ADAPT-232S and ADAPT-S, that had standardized contents of salidroside, schisandrin, eleutherosides B and E, ecdisterone and pantothenic acid. Methods: Standard psychological scales and computerized neurophysiological and blood tests were used to assess the efficacy of the treatments at the baseline and then after 7, 8, 28 and 29 days of daily oral administration. Fatigue was chosen as one of the primary outcomes and was measured as selective inattention and impulsivity in the Conners’ computerized continuous performance test (CCPT) and three standard psychological rating scales, the fatigue severity score (FSS), the perceived stress score (PSS) and the Shirom-Melamed burnout score (SMBS). The anabolic index (blood testosterone/cortisol ratio) and blood lactate were selected as primary outcomes in the phase of recovery of athletes on the second day after heavy physical exercise or competitions. Results: Significant differences (p<0.01) between the placebo and verum groups in favor of ADAPT-232S and ADAPT-S were found in the primary and some secondary outcomes: Conners’ computerized continuous performance test parameters of selective attention and impulsivity, anabolic index, cortisol and lactate levels in blood, fatigue severity score, perceived stress score, and physical performance tests. The sport achievements of athletes were in favor of the ADAPT groups. All of the treatments were well tolerated. The total numbers of adverse events did not differ among the three groups. Conclusions: The adaptogenic preparations, ADAPT-232S or ADAPT-S, are safe and effective supplements for enhancing tolerance to physical and emotional stress as well as for the recovery of athletes during and after high–intensity exercise and competitions.