Effects of TiO2 Nanoparticles on Human Myelomonocytic Cell Line THP-1

Effects of TiO₂ Nanoparticles on Human Myelomonocytic Cell Line THP-1

The frequency of exposure to nanoparticles has remarkably increased throughout recent years. Titanium dioxide (TiO₂) materials are commonly used for consumer and health care products as well as for technical and medicinal applications. Recently, both suppressive and stimulatory effects of TiO₂ nanoparticles on human peripheral blood mononuclear cells have been shown, indicating T-cell - macrophage interactions to be an important target for nanoparticle action.
To address the impact of nanoparticles on isolated monocytes, we investigated effects of TiO₂ nanoparticles on the human myelomonocytic cell line THP-1 in vitro and monitored the influence
of particle treatment on tryptophan breakdown in unstimulated and lipopolysaccharide (LPS)-stimulated cells in this study.