Effect of Differently Regioselective Chitosan Sulfates on Serum Lipids in Alloxan induced Diabetic Rats

Effect of Differently Regioselective Chitosan Sulfates on Serum Lipids in Alloxan induced Diabetic Rats

Objective: Diabetes mellitus is the most common endocrine disorder, and sometimes accompanied by long-term complications, which mainly was resulted in insufficient metabolic control. In this paper, we investigated and compared the hypolipidemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats.

Methods: Compared with the normal control rats, no noticeable changes were found in serum lipid levels in the diabetes rats. Except 3-O-sulfochitosan (TCTS), other chitosan sulfates exhibit mild lipid regulating activities at different doses and time.

Results: First, TCTS significantly elevated the serum cholesterol level, however, TCTS also notably increased HDL-C level. HDL-C is a kind of the important criteria of antiatherogenic agents. Many studies have showed that the higher level of HDL-C lead to the lower incidence of cardiovascular diseases. Second, treatment with TCTS the plasma insulin levels were obviously increased in the diabetic rats. Insulin deficiency in diabetes mellitus has been demonstrated to bring about various disorders in metabolic and regulatory processes, which in turn causes to accumulation of lipids.

Conclusions: Therefore, in terms of the effect of TCTS for HDL-C and serum insulin level, TCTS might be has a lipid lowering effect on the alloxan-induced diabetic rats.