Diclofenac Rechallange Induced Fatal Toxic Epidermal Necrolysis

Lyell’s syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. It can be due to a many drugs including non steroidal anti-inflammatory drugs. We report a case of fatal Lyell’s syndrome after oral readministration of diclofenac in a patient with a history of diclofenac related Stevens-Johnson syndrome four years previously.